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Data sheet of Rabbit Polyclonal to NTAL / LAB
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Polyclonal |
More info about Rabbit Polyclonal to NTAL / LAB
| Brand: | Exbio |
| Product no.: | 11-485-C025 |
| Product type: | Primary antibodies |
| Host species: | Rabbit |
| Product name: | Rabbit Polyclonal to NTAL / LAB |
| Antigen: | NTAL / LAB |
| Clonality: | Polyclonal |
| Negative species: | Mouse |
| Clone: | Polyclonal |
| Immunogen: | Recombinant cytoplasmic domain (aa 91-243) of human NTAL._x000D_ |
| Format: | purified |
| Specificity: | The polyclonal antibody recognizes the defined epitope (aa 91-243) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells. _x000D_ _x000D_ _x000D_ |
| Categories: | Adaptor Proteins (Human), Adaptor Proteins |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified from rabbit serum by affinity chromatography |
| Product specific references: | *Tkaczyk C, Horejsi V, Iwaki S, Draber P, Samelson LE, Satterthwaite AB, Nahm DH, Metcalfe DD, Gilfillan AM: NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation. Blood. 2004 Jul 1;104(1):207-14. _x000D_ |
| General references: | *Horejsà V, Zhang W, Schraven B.: Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat Rev Immunol. 2004 Aug;4(8):603-16., *Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, Saito T.: LAT and NTAL mediate immunoglobulin E-induced sustained extracellular_x000D_ signal-regulated kinase activation critical for mast cell survival. Mol Cell Biol. 2007 Jun;27(12):4406-15._x000D_ |
| Related products: | - Rabbit Polyclonal to SLP65 / BLNK - Rabbit Polyclonal to PAG / Cbp - Rabbit Polyclonal to PDK1 / PDPK1 |
| Shipping condition: | Room temperature |