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Data sheet of Rabbit Polyclonal to SLP65 / BLNK
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Mouse |
| Clonality | Polyclonal |
More info about Rabbit Polyclonal to SLP65 / BLNK
| Brand: | Exbio |
| Product no.: | 11-411-C025 |
| Product type: | Primary antibodies |
| Host species: | Rabbit |
| Product name: | Rabbit Polyclonal to SLP65 / BLNK |
| Antigen: | SLP65 / BLNK |
| Clonality: | Polyclonal |
| Clone: | Polyclonal |
| Immunogen: | A fusion protein representing amino acids 171-356 of human BLNK. |
| Format: | purified |
| Specificity: | The polyclonal antibody reacts with mouse SLP65 / BLNK, a cytosolic adaptor protein identified as two phosphoproteins migrating at 68 and 70 kDa in SDS/PAGE (alternatively spliced forms of human SLP65). |
| Categories: | Adaptor Proteins (Rodent), Adaptor Proteins |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | SLP65 / BLNK (SH2 domain-containing leukocyte-specific phosphoprotein of 65 kDa; B cell linker protein), also known as BASH, is an adaptor protein that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). Phosphorylated by Syk tyrosine kinase, SLP65 serves as a scaffold for Btk tyrosine kinase, Vav1 guanine nucleotide exchange factor, phospholipase C gamma2, as well as Grb2 and Nck adaptor proteins; thus represents a central linker protein that bridges the BCR-associated kinases with a multitude of signaling pathways. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified from rabbit serum by precipitation methods |
| General references: | *Koretzky GA, Abtahian F, Silverman MA: SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond. Nat Rev Immunol. 2006 Jan;6(1):67-78._x000D_ _x000D_ _x000D_ , *Kersseboom R, Ta VB, Zijlstra AJ, Middendorp S, Jumaa H, van Loo PF, Hendriks RW: Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the_x000D_ induction of Ig light chain gene rearrangement. J Immunol. 2006 Apr 15;176(8):4543-52._x000D_ _x000D_ _x000D_ , *Kersseboom R, Middendorp S, Dingjan GM, Dahlenborg K, Reth M, Jumaa H, Hendriks RW: Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells. J Exp Med. 2003 Jul 7;198(1):91-8._x000D_ _x000D_ , *Jumaa H, Mitterer M, Reth M, Nielsen PJ: The absence of SLP65 and Btk blocks B cell development at the preB cell receptor-positive stage. Eur J Immunol. 2001 Jul;31(7):2164-9._x000D_ _x000D_ _x000D_ , *Fu C, Turck CW, Kurosaki T, Chan AC: BLNK: a central linker protein in B cell activation. Immunity. 1998 Jul;9(1):93-103._x000D_ _x000D_ _x000D_ |
| Related products: | - Rat Monoclonal to CD105 (mouse) - Rabbit Polyclonal to SLP76 - Rabbit Polyclonal to ZAP-70 |
| Shipping condition: | Room temperature |