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Data sheet of Mouse Monoclonal to LARGE1
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to LARGE1
| Brand: | Exbio |
| Product no.: | 1P-702-C100 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to LARGE1 |
| Antigen: | LARGE1 |
| Clonality: | Monoclonal |
| Clone: | LARGE-02 |
| Isotype: | IgG2b |
| Immunogen: | Recombinant fragment of human LARGE1 (amino acids 35-142) |
| Format: | PE |
| Specificity: | The mouse monoclonal antibody LARGE-02 recognizes human LARGE1, a glycosyltransferase localizing mainly to the Golgi apparatus. Crossreactivity with LARGE2 was not determined. |
| Categories: | Miscellaneous (Human) |
| Concentration: | 0.1 mg/ml |
| Storage buffer: | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide. |
| Storage / stability: | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. |
| Background: | LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells. |
| Usage: | The reagent is designed for Flow Cytometry analysis. |
| Preparation: | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate was purified by size-exclusion chromatography. |
| General references: | *Grewal PK, McLaughlan JM, Moore CJ, Browning CA, Hewitt JE: Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies. Glycobiology. 2005 Oct;15(10):912-23. |
| Related products: | - Mouse Monoclonal to LIME - Mouse Monoclonal to LAT - Mouse Monoclonal to Lck |
| Shipping condition: | Room temperature |