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Data sheet of Mouse Monoclonal to CD253 / TRAIL
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD253 / TRAIL
| Brand: | Exbio |
| Product no.: | 11-316-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD253 / TRAIL |
| Antigen: | CD253 / TRAIL |
| Clonality: | Monoclonal |
| Negative species: | Mouse, Other not tested |
| Clone: | 2E5 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant soluble fragment (aa 95-281) of human TRAIL. |
| Format: | purified |
| Specificity: | The antibody 2E5 reacts with TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues._x000D_ |
| Categories: | CD and Related Antigens (Human), Apoptosis (Human), Apoptosis |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Human CD253 / TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2). |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Plasilova M, Zivny J, Jelinek J, Neuwirtova R, Cermak J, Necas E, Andera L, Stopka T: TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia_x000D_ progenitors. Leukemia. 2002 Jan;16(1):67-73. _x000D_ , *Hyer ML, Croxton R, Krajewska M, Krajewski S, Kress CL, Lu M, Suh N, Sporn MB, Cryns VL, Zapata JM, Reed JC: Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. Cancer Res. 2005 Jun 1;65(11):4799-808. _x000D_ |
| Related products: | - Mouse Monoclonal to CD261 / TRAIL-R1 / DR4 - Mouse Monoclonal to CD255 / TWEAK - Mouse Monoclonal to CD26 |
| Shipping condition: | Room temperature |