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Data sheet of Mouse Monoclonal to CD261 / TRAIL-R1 / DR4
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD261 / TRAIL-R1 / DR4
| Brand: | Exbio |
| Product no.: | 11-403-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD261 / TRAIL-R1 / DR4 |
| Antigen: | CD261 / TRAIL-R1 |
| Clonality: | Monoclonal |
| Clone: | DR-4-02 |
| Isotype: | IgG1 |
| Immunogen: | Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1. |
| Format: | purified |
| Specificity: | The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines. |
| Categories: | Apoptosis (Human), CD and Related Antigens (Human), Apoptosis |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor). |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Simova S, Klima M, Cermak L, Sourkova V, Andera L: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis. 2008 Mar;13(3):423-36._x000D_ |
| General references: | *Corallini F, Milani D, Nicolin V, Secchiero P: TRAIL, caspases and maturation of normal and leukemic myeloid precursors. Leuk Lymphoma. 2006 Aug;47(8):1459-68._x000D_ _x000D_ _x000D_ |
| Related products: | - Mouse Monoclonal to CD264 / TRAIL-R4 - Mouse Monoclonal to CD262 / TRAIL-R2 - Mouse Monoclonal to CD263 / TRAIL-R3 |
| Shipping condition: | Room temperature |