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Mouse Monoclonal to CD4

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Data sheet of Mouse Monoclonal to CD4

BrandExbio
Product typePrimary antibodies
ReactivityHuman
ClonalityMonoclonal

More info about Mouse Monoclonal to CD4

Brand: Exbio
Product no.: 11-816-C100
Product type: Primary antibodies
Host species: Mouse
Product name: Mouse Monoclonal to CD4
Antigen: CD4
Clonality: Monoclonal
Clone: EM4
Isotype: IgG2a
Immunogen: Normal human blood lymphocytes
Format: purified
Specificity: The mouse monoclonal antibody EM4 recognizes CD4 antigen, a 55 kDa transmebrane glycoprotein expressed on a subset of T lymphocytes (“helper“ T-cells) and also on monocytes, tissue macrophages and granulocytes. This antibody does not block Leu3a and OKT4 binding, and blocks HIV-1 infection in cell to cell system. Very strong flow cytometry staining, brighter than Leu3a, OKT4 and other.
Categories: CD and Related Antigens (Human)
Concentration: 1 mg/ml
Storage buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage / stability: Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Background: CD4 (T4) is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. In extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). Transmembrane region forms 25 aa, cytoplasmic tail consists of 38 aa. Domains 1,2 and 4 are stabilized by disulfide bonds. The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains._x000D_ Extracellular ligands: MHC class II molecules (binds to CDR2-like region in CD4 domain 1); HIV envelope protein gp120 (binds to CDR2-like region in CD4 domain 1); IL-16 (binds to CD4 domain 3), Human seminal plasma glycoprotein gp17 (binds to CD4 domain 1), L-selectin_x000D_ Intracellular ligands: p56LckCD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (human immunodeficiency virus; CD4 is primary receptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction._x000D_ Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency).
Purity: > 95% (by SDS-PAGE)
Purification: Purified from hybridoma culture supernatant by protein-A affinity chromatography.
Product specific references: *Filatov AV, Krotov GI, Zgoda VG, Volkov Y: Fluorescent immunoprecipitation analysis of cell surface proteins: a methodology compatible with mass-spectrometry. J Immunol Methods. 2007 Jan 30;319(1-2):21-33.
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Shipping condition: Room temperature

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