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Data sheet of Mouse Monoclonal antibody to human TDG (Thymine DNA glycosylase)
| Brand | ProteoGenix |
| Product type | Primary antibodies |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Host species | Mouse |
| Applications | E, WB, IC, IP |
More info about Mouse Monoclonal antibody to human TDG (Thymine DNA glycosylase)
| Brand: | ProteoGenix |
| Proteogenix reference: | PTGX-TDG-1F5 |
| Product type: | Primary antibodies |
| Clonality: | Monoclonal |
| Product name: | Mouse Monoclonal antibody to human TDG (Thymine DNA glycosylase) |
| Host species: | Mouse |
| Target species: | Human |
| Reactivity: | Human, Mouse |
| Applications: | E, WB, IC, IP |
| Size: | 100µl |
| Clone name: | 1SJâ€1F5 |
| Uniprot: | #N/A |
| Immunogen: | recombinant mouse TDG protein, aa 32-421 |
| Specificity: | mouse and human TDG. |
| Dilution: | 1/500-1/5000 |
| Alternative names: | C JUN leucine zipper interactive protein antibody, C JUN leucine zipper interactive protein antibody, C-JUN leucine zipper interactive protein JZA-3 antibody, E130317C12Rik antibody, EC 3.2.2.29 antibody, G/T mismatch specific thymine DNA glycosylase antibody, G/T mismatch specific thymine DNA glycosylase antibody, G/T mismatch-specific thymine DNA glycosylase antibody, JZA 3 antibody, Jza1 antibody, T:G mismatch thymine glycosylase antibody, Tdg antibody, TDG_HUMAN antibody, Thymine DNA glycosylase antibody |
| Isotype: | IgG2b, k |
| Form: | liquid/frozen |
| Spec:conjugate/tag/label: | Unconjugated |
| Research area: | Epigenetics & Nuclear Signalling |
| Background information: | Mouse monoclonal anti-TDG (Thymine DNA glycosylase) antibodies, clone 1SJ-1F5, recognize mouse and human TDG. TDG is an enzyme that corrects G/T mispairs to G/C pairs that are produced in the DNA of higher eukaryotes by the hydrolytic deamination of 5-methylcytosine to thymine. It corrects it by hydrolyzing the carbon-nitrogen bond between the the sugar-phosphate backbone of the DNA and a mispaired thymine. The enzyme can also remove thymine from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no observable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also pull-out uracil and 5-bromouracil from mispairs with guanine. |
| Publications: | 1. Um S, Harbers M, Benecke A, Pierrat B, Losson R, Chambon P. Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase. J Biol Chem. 1998 Aug 14;273(33):20728-36. |
| Storage: | Store at -20°C. Aliquot to avoid repeated freezing and thawing. |
| Delivery lead time in business days in europe: | 2-3 |
| Delivery conditions: | Dry Ice |
| Image: |  |
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