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Data sheet of Mouse Monoclonal to SOCS3 / Suppressor of cytokine signaling
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to SOCS3 / Suppressor of cytokine signaling
| Brand: | Exbio |
| Product no.: | 11-406-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to SOCS3 / Suppressor of cytokine signaling |
| Antigen: | SOCS3 |
| Clonality: | Monoclonal |
| Clone: | SO1 |
| Isotype: | IgG2b |
| Immunogen: | Full-length SOCS3 protein. |
| Format: | purified |
| Specificity: | The antibody SO1 reacts with SOCS3, an intracellular cytokine signaling inhibitor. |
| Categories: | Cytokine Signaling (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Neuwirt H, Puhr M, Cavarretta IT, Mitterberger M, Hobisch A, Culig Z: Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion. Endocr Relat Cancer. 2007 Dec;14(4):1007-19. |
| General references: | *Miao T, Wu D, Zhang Y, Bo X, Xiao F, Zhang X, Magoulas C, Subang MC, Wang P, Richardson PM: SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase. Mol Cell Neurosci. 2008 Feb;37(2):367-75._x000D_ _x000D_ , *Elliott J: SOCS3 in Liver Regeneration and Hepatocarcinoma. Mol Interv. 2008 Feb;8(1):19-21._x000D_ _x000D_ _x000D_ , *Zhu BM, Ishida Y, Robinson GW, Pacher-Zavisin M, Yoshimura A, Murphy PM, Hennighausen L. SOCS3 Negatively Regulates the gp130-STAT3 Pathway in Mouse Skin Wound Healing. J Invest Dermatol. 2008 Jan 10_x000D_ _x000D_ , *Kimura A, Kinjyo I, Matsumura Y, Mori H, Mashima R, Harada M, Chien KR, Yasukawa H, Yoshimura A. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem. 2004 Feb 20;279(8):6905-10._x000D_ _x000D_ , *Yu CR, Mahdi RM, Ebong S, Vistica BP, Gery I, Egwuagu CE: Suppressor of cytokine signaling 3 regulates proliferation and activation of T-helper cells. J Biol Chem. 2003 Aug 8;278(32):29752-9._x000D_ _x000D_ |
| Related products: | - Mouse Monoclonal to STAT1 (Phospho-Ser727) - Mouse Monoclonal to Sos - Mouse Monoclonal to STAT1 |
| Shipping condition: | Room temperature |