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Data sheet of Mouse Monoclonal to OPAL1
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to OPAL1
| Brand: | Exbio |
| Product no.: | 11-699-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to OPAL1 |
| Antigen: | OPAL1 |
| Clonality: | Monoclonal |
| Clone: | OPAL1-01 |
| Isotype: | IgG2a |
| Immunogen: | Recombinant fragment of human OPAL1 (amino acids 152-342) |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody OPAL1-01 recognizes OPAL1 (outcome predictor in acute leukemia 1), a transmembrane adaptor protein expressed mainly by megacaryocytes and platelets. |
| Categories: | Adaptor Proteins (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | OPAL1 (outcome predictor in acute leukemia 1) is an almost uncharacterized transmembrane adaptor protein expressed mainly by megacaryocytes and platelets. Its expression is enhanced on TEL/AML leukemic cells. The function of OPAL1 is unknown, although the presence of a cytochrome c-like heme-binding site and a transmembrane domain suggested OPAL1 may be involved in the mitochondrial electron transport chain. Its originally reported prognostic impact appears to be treatment dependent. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| General references: | *Holleman A, den Boer ML, Cheok MH, Kazemier KM, Pei D, Downing JR, Janka-Schaub GE, Göbel U, Graubner UB, Pui CH, Evans WE, Pieters R: Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols. Blood. 2006 Sep 15;108(6):1984-90. |
| Related products: | - Mouse Monoclonal to PAC-1 - Mouse Monoclonal to p21Waf1 - Mouse Monoclonal to p53 (Phospho-Ser392) |
| Shipping condition: | Room temperature |