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Data sheet of Mouse Monoclonal to CD54 / ICAM-1
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD54 / ICAM-1
| Brand: | Exbio |
| Product no.: | 11-229-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD54 / ICAM-1 |
| Antigen: | CD54 |
| Clonality: | Monoclonal |
| Clone: | MEM-112 |
| Isotype: | IgG1 |
| Immunogen: | Raji Burkitt's lymphoma cell line Raji |
| Format: | purified |
| Specificity: | The antibody MEM-112 reacts with CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus). The expression of CD54 is upregulated by activation; it is expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells. _x000D_ HLDA VI; WS Code AS A050_x000D_ |
| Categories: | CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation. _x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Leeuwenberg JF, Smeets EF, Neefjes JJ, Shaffer MA, Cinek T, Jeunhomme TM, Ahern TJ, Buurman WA.: E-selectin and intercellular adhesion molecule-1 are released by activated_x000D_ human endothelial cells in vitro. Immunology. 1992 Dec;77(4):543-9. , *Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997). |
| Related products: | - Mouse Monoclonal to CD57 - Mouse Monoclonal to CD55 / DAF - Mouse Monoclonal to CD56 / NCAM |
| Shipping condition: | Room temperature |