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Data sheet of Rat Monoclonal to CD5 (mouse)
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Mouse |
| Clonality | Monoclonal |
More info about Rat Monoclonal to CD5 (mouse)
| Brand: | Exbio |
| Product no.: | 11-748-C025 |
| Product type: | Primary antibodies |
| Host species: | Rat |
| Product name: | Rat Monoclonal to CD5 (mouse) |
| Antigen: | CD5 (mouse) |
| Clonality: | Monoclonal |
| Clone: | 53-7.3 |
| Isotype: | IgG2a |
| Immunogen: | mouse thymus or spleen cells |
| Format: | purified |
| Specificity: | The rat monoclonal antibody 53-7.3 recognizes CD5, a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B-1 lymphocytes. |
| Categories: | CD and Related Antigens & MHC (Rodent) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD5 (T1) is a single-chain transmembrane glycoprotein expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified from cell culture supernatant by protein-G affinity chromatography. |
| Product specific references: | *Wang JY, Lee J, Yan M, Rho JH, Roehrl MH: Dermatan sulfate interacts with dead cells and regulates CD5(+) B-cell fate: implications for a key role in autoimmunity. Am J Pathol. 2011 May;178(5):2168-76., *Sestero CM, McGuire DJ, De Sarno P, Brantley EC, Soldevila G, Axtell RC, Raman C: CD5-dependent CK2 activation pathway regulates threshold for T cell anergy. J Immunol. 2012 Sep 15;189(6):2918-30, *Jeong YI, Hong SH, Cho SH, Lee WJ, Lee SE: Induction of IL-10-producing CD1dhighCD5+ regulatory B cells following Babesia microti-infection. PLoS One. 2012;7(10):e46553. doi: 10.1371/journal.pone.0046553. |
| Related products: | - Rat Monoclonal to CD86 (mouse) - Rat Monoclonal to CD54 (mouse) - Rat Monoclonal to CD62L / L-Selectin (mouse) |
| Shipping condition: | Room temperature |