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Data sheet of Mouse Monoclonal to CD49c / Integrin alpha 3
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to CD49c / Integrin alpha 3
| Brand: | Exbio |
| Product no.: | 11-137-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to CD49c / Integrin alpha 3 |
| Antigen: | CD49c / Integrin alpha 3 |
| Clonality: | Monoclonal |
| Clone: | ASC-1 |
| Isotype: | IgG1 |
| Immunogen: | Human SSC-9 cell line (squamous cell carcinoma) |
| Format: | purified |
| Specificity: | The mouse monoclonal antibody ASC-1 recognizes CD49c (integrin alpha 3), a transmembrane glycoprotein composed of disulfide linked 125 kDa and 30 kDa chains, and expressed on adherent cell lines and to a lesser extent on T and B cells and monocytes._x000D_ _x000D_ HLDA VI; WS Code A002 |
| Categories: | CD and Related Antigens (Human) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | CD49c / Integrin alpha 3 is a type I transmembrane glycoprotein proteolytically cleaved into two disulfide linked chains. It noncovalently associates with CD29 (integrin beta 1) to form the VLA-3 complex, an adhesion receptor for extracellular matrix components (fibronectin, laminin 1, laminin 5, entactin, and collagen). It is expressed on adherent cells, mainly on fibroblasts, epithelial cells and endothelial cells. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Skubitz AP, Bast RC, Wayner EA, Letourneau PC, Wilke MS: Expression of alpha 6 and beta 4 integrins in serous ovarian carcinoma correlates with expression of the basement membrane protein laminin. Am J Pathol. 1996 May;148(5):1445-61., *Pattaramalai S, Skubitz KM, Skubitz AP: A novel recognition site on laminin for the alpha 3 beta 1 integrin. Exp Cell Res. 1996 Feb 1;222(2):281-90. |
| Related products: | - Mouse Monoclonal to CD5 / T1 - Mouse Monoclonal to CD49d / Integrin alpha 4 - Mouse Monoclonal to CD5 |
| Shipping condition: | Room temperature |