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Data sheet of Hamster Monoclonal to Bim (mouse)
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Mouse |
| Clonality | Monoclonal |
More info about Hamster Monoclonal to Bim (mouse)
| Brand: | Exbio |
| Product no.: | 11-569-C025 |
| Product type: | Primary antibodies |
| Host species: | Hamster |
| Product name: | Hamster Monoclonal to Bim (mouse) |
| Antigen: | Bim (mouse) |
| Clonality: | Monoclonal |
| Clone: | Ham151-149 |
| Isotype: | IgG1 |
| Immunogen: | Mouse BimL (w/o transmembrane region) + Bcl-xL (w/o transmembrane region)-6-his tag, purified from Hi5 cells_x000D_ |
| Format: | purified |
| Specificity: | The Armenian hamster antibody Ham151-149 reacts with mouse Bim, a 19-24 kDa pro-apoptotic protein (Bcl-2 family) which regulates immunological responses._x000D_ |
| Categories: | Apoptosis (Rodent) |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Bim (Bcl2-interacting mediator) is a pro-apoptotic protein of BH3 domain-only subgroup of the Bcl2 family. It has important roles in initiation of apoptosis in response to many death stimuli. Bim is an important regulator of B and T cell negative selection and is also an essential regulator of T cell apoptosis during termination of an immune response. Bim is constitutively expressed in many cell types but it is maintained in an inactive form through binding to the microtubule-associated dynein motor complex._x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Jorgensen TN, McKee A, Wang M, Kushnir E, White J, Refaeli Y, Kappler JW, Marrack P: Bim and Bcl-2 mutually affect the expression of the other in T cells. J Immunol. 2007 Sep 15;179(6):3417-24., *Oliver PM, Wang M, Zhu Y, White J, Kappler J, Marrack P: Loss of Bim allows precursor B cell survival but not precursor B cell differentiation in the absence of interleukin 7. J Exp Med. 2004 Nov 1;200(9):1179-87._x000D_ |
| General references: | *Wang X, Xing D, Liu L, Chen WR: BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis. FEBS Lett. 2009 May 8. [Epub ahead of print]_x000D_ , *Yang Y, Zhao Y, Liao W, Yang J, Wu L, Zheng Z, Yu Y, Zhou W, Li L, Feng J, Wang H, Zhu WG: Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. Neoplasia. 2009 Apr;11(4):313-24._x000D_ , *Ludwinski MW, Sun J, Hilliard B, Gong S, Xue F, Carmody RJ, Devirgiliis J, Chen YH: Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice. J Clin Invest. 2009 May 1. pii: 37619. doi: 10.1172/JCI37619. [Epub ahead of print]_x000D_ , *Snow AL, Oliveira JB, Zheng L, Dale JK, Fleisher TA, Lenardo MJ: Critical role for BIM in T cell receptor restimulation-induced death. Biol Direct. 2008 Aug 20;3:34._x000D_ , *Hughes P, Bouillet P, Strasser A: Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases. Curr Dir Autoimmun. 2006;9:74-94._x000D_ |
| Related products: | - Hamster Monoclonal to CD3 (mouse) - Hamster Monoclonal to CD154 / CD40L (mouse) - Hamster Monoclonal to CD28 (mouse) |
| Shipping condition: | Room temperature |