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Data sheet of Mouse Monoclonal to ARAP1 / centaurin
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to ARAP1 / centaurin
| Brand: | Exbio |
| Product no.: | 11-516-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to ARAP1 / centaurin |
| Antigen: | ARAP1 |
| Clonality: | Monoclonal |
| Clone: | ARAP1-2 |
| Isotype: | IgG1 |
| Immunogen: | His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1 |
| Format: | purified |
| Specificity: | The antibody ARAP1-2 reacts with C-terminal part of ARAP1, a 160 kDa adaptor protein. |
| Categories: | Signaling of Small GTPases (Human), Adaptor Proteins (Human), Apoptosis (Human), Adaptor Proteins, Signaling of Small GTPases, Apoptosis |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading. |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Simova S, Klima M, Cermak L, Sourkova V, Andera L: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis. 2008 Mar;13(3):423-36._x000D_ _x000D_ |
| General references: | *Guo DF, Chenier I, Tardif V, Orlov SN, Inagami T: Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane. Biochem Biophys Res Commun. 2003 Oct 31;310(4):1254-65._x000D_ _x000D_ _x000D_ , *Miura K, Jacques KM, Stauffer S, Kubosaki A, Zhu K, Hirsch DS, Resau J, Zheng Y, Randazzo PA: ARAP1: a point of convergence for Arf and Rho signaling. Mol Cell. 2002 Jan;9(1):109-19._x000D_ _x000D_ _x000D_ |
| Related products: | - Mouse Monoclonal to Bcl2 - Mouse Monoclonal to ARHGEF4 / ASEF1 - Mouse Monoclonal to Basic Cytokeratins |
| Shipping condition: | Room temperature |