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Data sheet of Rabbit Polyclonal to Akt1 / PKB
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human |
| Clonality | Polyclonal |
More info about Rabbit Polyclonal to Akt1 / PKB
| Brand: | Exbio |
| Product no.: | 11-509-C050 |
| Product type: | Primary antibodies |
| Host species: | Rabbit |
| Product name: | Rabbit Polyclonal to Akt1 / PKB |
| Antigen: | Akt1 / PKB |
| Clonality: | Polyclonal |
| Clone: | Polyclonal |
| Immunogen: | Synthetic peptide (coupled with KLH) derived from aminoacid sequence 85-100 of human Akt1. This immunogen sequence has 100% homology with mouse and rat Akt1/PKB. |
| Format: | purified |
| Specificity: | The polyclonal antibody reacts with Akt1 (recognized epitope: between aa 85-100 of Akt1/PKB). Akt/PKB protein kinases family has a three mammalian members identified to date (Akt1, Akt2, Akt3). Human Akt1 has a predicted molecular weight of 55.7 kDa._x000D_ _x000D_ |
| Categories: | Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human), Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) |
| Concentration: | 1 mg/ml |
| Storage buffer: | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide. |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | Serine/threonine protein kinase Akt/PKB (Protein Kinase B) plays important roles in cell growth, metabolism, proliferation and survival. Upon extracellular stimulus that leads to activation of phosphatidylinositol 3-kinase (PI3K), Akt is recruited from the cytosol to the plasma membrane through binding 3´phosphoinositides and is phosphorylated. Active Akt dissociates from the plasma membrane to gain access to various substrates in different subcellular locations by translocating to cytosol and nucleus. _x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified from rabbit serum by affinity chromatography |
| General references: | *Ananthanarayanan B, Fosbrink M, Rahdar M, Zhang J: Live-cell molecular analysis of AKT activation reveals roles for activation loop phosphorylation. J Biol Chem. 2007 Oct 10. |
| Related products: | - Rabbit Polyclonal to Francisella tularensis ssp. tularensis antigen FTT0571 - Rabbit Polyclonal to CtBP1 / BARS - Rabbit Polyclonal to Francisella tularensis ssp. holarctica antigen FTL0187 |
| Shipping condition: | Room temperature |