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Data sheet of Mouse Monoclonal to AHNAK1
| Brand | Exbio |
| Product type | Primary antibodies |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
More info about Mouse Monoclonal to AHNAK1
| Brand: | Exbio |
| Product no.: | 11-540-C025 |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Product name: | Mouse Monoclonal to AHNAK1 |
| Antigen: | AHNAK1 |
| Clonality: | Monoclonal |
| Clone: | EM-09 |
| Isotype: | IgG1 |
| Immunogen: | Bacterially expressed fragment of N-terminal domain of human AHNAK1._x000D_ |
| Format: | purified |
| Specificity: | The antibody EM-09 reacts with AHNAK1, a 700 kDa multi-functional adaptor protein expressed mainly in epithelial cell, various types of muscle cells and immune cells._x000D_ |
| Categories: | Cytoskeleton: Actin System (Human), Transcription Regulation & Nuclear Proteins (Human), Calcium Signaling (Human), Adaptor Proteins (Human), Cytoskeleton: Actin System (Rodent), Cytoskeleton: Actin System, Transcription Regulation & Nuclear Proteins (Rodent), Transcription Regulation & Nuclear Proteins, Adaptor Proteins, Adaptor Proteins (Rodent), Calcium Signaling (Rodent), Calcium Signaling |
| Concentration: | 1 mg/ml |
| Storage buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage / stability: | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label. |
| Background: | AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear; it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex. _x000D_ |
| Purity: | > 95% (by SDS-PAGE) |
| Purification: | Purified by protein-A affinity chromatography |
| Product specific references: | *Johnson EK, Zhang L, Adams ME, Phillips A, Freitas MA, Froehner SC, Green-Church KB, Montanaro F: Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins. PLoS One. 2012;7(8):e43515. doi: 10.1371/journal.pone.0043515. |
| General references: | *Matza D, Badou A, Kobayashi KS, Goldsmith-Pestana K, Masuda Y, Komuro A, McMahon-Pratt D, Marchesi VT, Flavell RA: A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. Immunity. 2008 Jan;28(1):64-74., *Haase H, Alvarez J, Petzhold D, Doller A, Behlke J, Erdmann J, Hetzer R, Regitz-Zagrosek V, Vassort G, Morano I: Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its_x000D_ beta-adrenergic regulation. FASEB J. 2005 Dec;19(14):1969-77., *Sussman J, Stokoe D, Ossina N, Shtivelman E: Protein kinase B phosphorylates AHNAK and regulates its subcellular localization. J Cell Biol. 2001 Sep 3;154(5):1019-30., *Gentil BJ, Delphin C, Mbele GO, Deloulme JC, Ferro M, Garin J, Baudier J: The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B._x000D_ J Biol Chem. 2001 Jun 29;276(26):23253-61. |
| Related products: | - Mouse Monoclonal to alpha-Fetoprotein - Mouse Monoclonal to Albumin - Mouse Monoclonal to alpha, beta-tubulin dimer |
| Shipping condition: | Room temperature |