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Data sheet of CTLA4 monoclonal antibody, clone ANC152.2/8H5
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Human |
| Host species | Mouse |
| Applications | EIA,Flow Cyt |
More info about CTLA4 monoclonal antibody, clone ANC152.2/8H5
| Brand: | Abnova |
| Reference: | MAB6927 |
| Product name: | CTLA4 monoclonal antibody, clone ANC152.2/8H5 |
| Product description: | Mouse monoclonal antibody raised against CTLA4. |
| Clone: | ANC152.2/8H5 |
| Isotype: | IgG1, kappa |
| Gene id: | 1493 |
| Gene name: | CTLA4 |
| Gene alias: | CD152|CELIAC3|CTLA-4|GSE|IDDM12 |
| Gene description: | cytotoxic T-lymphocyte-associated protein 4 |
| Immunogen: | A mixture of stimulated human PBL's and human CTLA4 Ig fusion protein. |
| Form: | Liquid |
| Recommend dilutions: | The optimal working dilution should be determined by the end user. |
| Storage buffer: | In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate) |
| Storage instruction: | Store at 4°C. |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Antigen species / target species: | Human |
| Specificity: | MAB6927 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory cells in Vitro. It can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model. |
| Reactivity: | Human |
| Application image: |  |
| Application image note: | CTLA4 monoclonal antibody, clone ANC152.2/8H5 (Cat # MAB6927) blocked the binding of recombinant CTLA4-muIg fusion protein/R-PE conjugate to CD80 and CD86 expressed on human Raji cells. |
| Applications: | EIA,Flow Cyt |
| Shipping condition: | Blue Ice |
| Publications: | Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells.Kitani A, Chua K, Nakamura K, Strober W. J Immunol. 2000 Jul 15;165(2):691-702. |