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Data sheet of CD46 monoclonal antibody, clone MEM-258 (PE)
| Brand | Abnova |
| Product type | Primary antibodies |
| Reactivity | Bovine,Human |
| Host species | Mouse |
| Applications | WB,IP,Flow Cyt |
More info about CD46 monoclonal antibody, clone MEM-258 (PE)
| Brand: | Abnova |
| Reference: | MAB4442 |
| Product name: | CD46 monoclonal antibody, clone MEM-258 (PE) |
| Product description: | Mouse monoclonal antibody raised against native CD46. |
| Clone: | MEM-258 |
| Isotype: | IgG1 |
| Gene id: | 4179 |
| Gene name: | CD46 |
| Gene alias: | MCP|MGC26544|MIC10|TLX|TRA2.10 |
| Gene description: | CD46 molecule, complement regulatory protein |
| Immunogen: | Native purified CD46 from human T cell line HPB-ALL. |
| Form: | Liquid |
| Recommend dilutions: | Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension) The optimal working dilution should be determined by the end user. |
| Storage buffer: | In PBS (0.2% BSA, 0.09% sodium azide) |
| Storage instruction: | Store in the dark at 4°C. Do not freeze. Avoid prolonged exposure to light. Aliquot to avoid repeated freezing and thawing. |
| Note: | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
| Conjugate tag: | PE |
| Product type: | Primary antibodies |
| Host species: | Mouse |
| Antigen species / target species: | Human |
| Specificity: | This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 KDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes. |
| Reactivity: | Bovine,Human |
| Application image: |  |
| Application image note: | Surface staining of human peripheral blood cells with CD46 monoclonal antibody, clone MEM-258 (PE) (Cat # MAB4442). |
| Applications: | WB,IP,Flow Cyt |
| Shipping condition: | Blue Ice |
| Publications: | Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation.Oliaro J, Pasam A, Waterhouse NJ, Browne KA, Ludford-Menting MJ, Trapani JA, Russell SM. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18685-90. Epub 2006 Nov 20. |