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Human IL33 Recombinant Protein View larger

Human IL33 Recombinant Protein

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Data sheet of Human IL33 Recombinant Protein

BrandProteoGenix
Product typeProteins
Origin speciesHuman
Host speciesEscherichia coli (E. coli)

More info about Human IL33 Recombinant Protein

Proteogenix reference: PX-P3027-10
Protein delivered with tag?: Yes
Size: 10 ug
Product name: Human IL33 Recombinant Protein
Fragment type: Partial
Expression system: Prokaryotic expression
Molecular weight with tag if any: 32.02 kDa
Purity estimated: 0.95
Ncbi reference: O95760
Uniprot id: O95760
Uniprot link: http://www.uniprot.org/uniprot/O95760
Aliases / synonyms: DV27, C9ORF26, IL1F11, NFHEV, Interleukin-1 Family, Member 11, Nuclear factor from high endothelial venules, Interleukin 33, IL33
Protein sequence (w/o tag): MAMKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNHLALIKVDSSENLCTENILFKLSETLEHHHHHH
Form: Frozen
Buffer: PBS,pH 7.5 urea +8M
Storage condition: 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Delivery condition: Dry Ice
Delivery lead time in business days: 10-25
Image: PX-P3027.jpg
Description: Interleukin 33 (IL33) is a protein that in humans is encoded by the IL33 gene, it is a part of the IL-1 family and the protein is involved in the maturation of T helper 2 (Th2) cells inducing the secretion of T-helper type 2-associated cytokines. It acts also as a chemo-attractant for Th2. IL33 is a ligand for ST2 an IL-1 family receptor that is highly expressed on Th2 cells, mast cells and group 2 innate lymphocytes. IL33 is expressed by a large variety of cell types as fibroblasts, dendritic cells, epithelial cells, macrophages etc. IL33 has been related with multiples disease as asthma, allergy, endometriosis and hay fever.
Publications: 1: Zhang J, Wang Z, Xu Z, Han Z, Tao J, Lu P, Huang Z, Zhou W, Zhao C, Tan R, Gu M. The Potential Role of IL-33 in Renal Transplant Recipients with Chronic Allograft Dysfunction. Ann Transplant. 2016 Oct 4;21:611-618. PubMed PMID: 27698337. 2: Xu W, Liu Y, Ye D. Association between IL-33 Gene Polymorphisms (rs1929992, rs7044343) and Systemic Lupus Erythematosus in a Chinese Han Population. Immunol Invest. 2016 Oct;45(7):575-83. doi: 10.1080/08820139.2016.1193868. Epub 2016 Sep 7. PubMed PMID: 27603301. 3: Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV. Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8765-70. doi: 10.1073/pnas.1601914113. Epub 2016 Jul 18. PubMed PMID: 27432971; PubMed Central PMCID: PMC4978244. 4: Vaccaro M, Cicero F, Mannucci C, Calapai G, Spatari G, Barbuzza O, Cannavò SP, Gangemi S. IL-33 circulating serum levels are increased in patients with non-segmental generalized vitiligo. Arch Dermatol Res. 2016 Sep;308(7):527-30. doi: 10.1007/s00403-016-1675-2. Epub 2016 Jul 7. PubMed PMID: 27388717. 5: Feng Y, Zhu Y, Luo G, Wang Z, Yu P, Zheng L. [Expression and clinical significance of IL-33 in patients with non-small cell lung cancer]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Jun;32(6):808-11. Chinese. PubMed PMID: 27371849. 6: Sei H, Oshima T, Shan J, Wu L, Yamasaki T, Okugawa T, Kondo T, Tomita T, Fukui H, Watari J, Miwa H. Esophageal Epithelial-Derived IL-33 Is Upregulated in Patients with Heartburn. PLoS One. 2016 Apr 25;11(4):e0154234. doi: 10.1371/journal.pone.0154234. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0158932. PubMed PMID: 27111066; PubMed Central PMCID: PMC4844101. 7: Kudinova AY, Deak T, Hueston CM, McGeary JE, Knopik VS, Palmer RH, Gibb BE. Cross-species evidence for the role of interleukin-33 in depression risk. J Abnorm Psychol. 2016 May;125(4):482-94. doi: 10.1037/abn0000158. Epub 2016 Apr 7. PubMed PMID: 27054346; PubMed Central PMCID: PMC4850099. 8: Zhang J, Wang P, Ji W, Ding Y, Lu X. Overexpression of interleukin-33 is associated with poor prognosis of patients with glioma. Int J Neurosci. 2017 Mar;127(3):210-217. doi: 10.1080/00207454.2016.1175441. Epub 2016 Apr 24. PubMed PMID: 27050560. 9: Yue J, Tong Y, Xie L, Ma T, Yang J. Genetic variant in IL-33 is associated with idiopathic recurrent miscarriage in Chinese Han population. Sci Rep. 2016 Mar 30;6:23806. doi: 10.1038/srep23806. PubMed PMID: 27026387; PubMed Central PMCID: PMC4812300. 10: Wang Z, Xu L, Chang Y, Zhou L, Fu H, Zhang W, Yang Y, Xu J. IL-33 is associated with unfavorable postoperative survival of patients with clear-cell renal cell carcinoma. Tumour Biol. 2016 Aug;37(8):11127-34. doi: 10.1007/s13277-016-4879-3. Epub 2016 Mar 1. PubMed PMID: 26926076. 11: Rössle M, Cathomas G, Bonapace L, Sachs M, Dehler S, Storz M, Huber G, Moch H, Junt T, Mertz KD. Interleukin-33 Expression Indicates a Favorable Prognosis in Malignant Salivary Gland Tumors. Int J Surg Pathol. 2016 Aug;24(5):394-400. doi: 10.1177/1066896916633856. Epub 2016 Feb 23. PubMed PMID: 26912475. 12: Saadah OI, Al-Harthi SE, Al-Mughales JA, Bin-Taleb YY, Baeshen RS. Serum Interleukin-33 level in Saudi children with inflammatory bowel disease. Int J Clin Exp Pathol. 2015 Dec 1;8(12):16000-6. eCollection 2015. PubMed PMID: 26884875; PubMed Central PMCID: PMC4730088. 13: Porsbjerg C, Baines K, Gibson P, Bergqvist A, Erjefält JS, Sverrild A, Backer V. IL-33 is related to innate immune activation and sensitization to HDM in mild steroid-free asthma. Clin Exp Allergy. 2016 Apr;46(4):564-74. doi: 10.1111/cea.12702. PubMed PMID: 26748611. 14: Koca SS, Pehlivan Y, Kara M, Alibaz-Oner F, Oztuzcu S, Yilmaz N, Cetin GY, Kisacik B, Ozgen M, Pamuk ON, Direskeneli H, Sayarlioglu M, Onat AM. The IL-33 gene is related to increased susceptibility to systemic sclerosis. Rheumatol Int. 2016 Apr;36(4):579-84. doi: 10.1007/s00296-015-3417-8. Epub 2016 Jan 7. PubMed PMID: 26743213. 15: Bu X, Zhang T, Wang C, Ren T, Wen Z. IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production. J Transl Med. 2015 Dec 16;13:381. doi: 10.1186/s12967-015-0745-0. PubMed PMID: 26675669; PubMed Central PMCID: PMC4681137.

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