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MousePAD2 Protein-arginine deiminase type-2 Mouse Recombinant Protein-10 ug View larger

MousePAD2 Protein-arginine deiminase type-2 Mouse Recombinant Protein-10 ug

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Data sheet of MousePAD2 Protein-arginine deiminase type-2 Mouse Recombinant Protein-10 ug

BrandProteoGenix
Product typeProteins
Origin speciesMouse
Host speciesInsect

More info about MousePAD2 Protein-arginine deiminase type-2 Mouse Recombinant Protein-10 ug

Proteogenix reference: PX-P3022-10
Product name: MousePAD2 Protein-arginine deiminase type-2 Mouse Recombinant Protein-10 ug
Description: Mouse PAD2 (PADI2) is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions.

PADI2 has peptidylarginine deiminase activity against synthetic substrates. PAD2 is mainly expressed in the central nervous system, skeletal muscle, spinal cord, cerebrum, cerebellum, and submaxillary gland. Protein arginine deiminase type-2 plays a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis.

Eukaryote expression systems and more specifically Insect cells are used at ProteoGenix to produce mouse PAD2 recombinant protein with appropriate post translational modifications.
Related products: Human PAD2
Mouse PAD4
Human PAD4
Protein delivered with tag?: Yes
Size: 10 ug
Fragment type: Full-length
Expression system: Eukaryotic expression
Molecular weight with tag if any: 79.36 kDa
Purity estimated: 0.95
Ncbi reference: NP_032838.2
Uniprot id: Q08642
Uniprot link: http://www.uniprot.org/uniprot/Q08642
Aliases / synonyms: PAD-H19, PAD2, PADI2, Peptidylarginine deiminase II
Protein sequence (w/o tag): MGASWSHPQFEKGGGSGGGSGGSAWSHPQFEKMQPPIRENMLRERTVRLQYGSRVEAVYVLGTQLWTDVYSAAPAGAKTFSLKHSEGVKVEVVRDGEAEEVVTNGKQRWALSPSSTLRLSMAQASTEASSDKVTVNYYEEEGSAPIDQAGLFLTAIEISLDVDADRDGEVEKNNPKKASWTWGPEGQGAILLVNCDRDTPWLPKEDCSDEKVYSKQDLQDMSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRQKLYHVVKYTGGSAELLFFVEGLCFPDESFSGLVSIHVSLLEYMAEGIPLTPIFTDTVMFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYMNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPIKQLLGPDFGYVTREPLFETVTSLDSFGNLEVSPPVTVNGKEYPLGRILIGSSFPLSGGRRMTKVVRDFLQAQQVQAPVELYSDWLTVGHVDEFMTFIPIPGKKEFRLLMASTSACYQLFREKQKAGHGEAVMFKGLGGMSSKRITINKILSNESLTQENQYFQRCLDWNRDILKRELALTEKDIIDLPALFKMDENHQARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLETHVRGLLEPLGLACTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP
Form: Frozen
Buffer: PBS,pH 7.5
Storage condition: 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Delivery condition: Dry Ice
Biological activity: Calcium-dependent critrullination activity of the recombinant PAD2 was confirmed with Fibrinogen as substrate (detection of critrullinated fibrinogen by ELISA).
Delivery lead time in business days: 2-3
Image: PAD2-Mouse.jpg
Publications: 1. F. Arnoux and al (2017).
Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types.

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