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Human Gastricsin(PGII)/PGC Recombinant Protein View larger

Human Gastricsin(PGII)/PGC Recombinant Protein

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Data sheet of Human Gastricsin(PGII)/PGC Recombinant Protein

BrandProteoGenix
Product typeProteins
Origin speciesHuman
Host speciesMammalian

More info about Human Gastricsin(PGII)/PGC Recombinant Protein

Proteogenix reference: PX-P3001-10
Protein delivered with tag?: Yes
Size: 10 ug
Product name: Human Gastricsin(PGII)/PGC Recombinant Protein
Fragment type: Full-length
Expression system: Eukaryotic expression
Molecular weight with tag if any: 43.33 kDa
Purity estimated: 0.9
Protein accession: P20142
Spec:ncbi gene aliases: PGC
Spec:swissprotid: P20142.1
Ncbi reference:  P20142
Uniprot id: P20142
Uniprot link: http://www.uniprot.org/uniprot/P20142
Aliases / synonyms: Pepsinogen C, Gastricsin, PGC
Protein sequence (w/o tag): MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAAGSHHHHHH
Form: Frozen
Buffer: PBS, pH 7.5
Storage condition: 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Delivery condition: Dry Ice
Delivery lead time in business days: 5-7
Image: PX-P3001.jpg
Description: Pepsinogen C (progastricsin), also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsin C, the activated protease is a digestive enzyme that is produced in the stomach and constitutes a main component of the gastric mucosa. At low pH conditions, pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were declined or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were noticed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in diverse ways in different cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.
Publications: 1: Kumar S, Kumari N, Mittal RD, Ghoshal UC. Pepsinogen-II 100 bp ins/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia. Gastric Cancer. 2016 Jul;19(3):808-16. doi: 10.1007/s10120-015-0550-8. Epub 2015 Oct 20. PubMed PMID: 26486507. 2: He C, Xu Q, Tu H, Sun L, Gong Y, Liu J, Yuan Y. Polymorphic rs9471643 and rs6458238 upregulate PGC transcription and protein expression in overdominant or dominant models. Mol Carcinog. 2016 May;55(5):586-99. doi: 10.1002/mc.22305. Epub 2015 Apr 7. PubMed PMID: 25857852. 3: He CY, Sun LP, Xu Q, Liu JW, Jiang JY, Dong NN, Yuan Y. PGC TagSNP and its interaction with H. pylori and relation with gene expression in susceptibility to gastric carcinogenesis. PLoS One. 2014 Dec 31;9(12):e115955. doi: 10.1371/journal.pone.0115955. eCollection 2014. PubMed PMID: 25551587; PubMed Central PMCID: PMC4281127. 4: Massarrat S, Haj-Sheykholeslami A, Mohamadkhani A, Zendehdel N, Aliasgari A, Rakhshani N, Stolte M, Shahidi SM. Pepsinogen II can be a potential surrogate marker of morphological changes in corpus before and after H. pylori eradication. Biomed Res Int. 2014;2014:481607. doi: 10.1155/2014/481607. Epub 2014 Jun 17. PubMed PMID: 25028655; PubMed Central PMCID: PMC4083213. 5: Yoshida T, Kato J, Inoue I, Yoshimura N, Deguchi H, Mukoubayashi C, Oka M, Watanabe M, Enomoto S, Niwa T, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Iwane M, Takeshita T, Ushijima T, Ichinose M. Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer. Int J Cancer. 2014 Mar 15;134(6):1445-57. doi: 10.1002/ijc.28470. Epub 2013 Oct 3. PubMed PMID: 24009139. 6: Cao XY, Jia ZF, Jin MS, Cao DH, Kong F, Suo J, Jiang J. Serum pepsinogen II is a better diagnostic marker in gastric cancer. World J Gastroenterol. 2012 Dec 28;18(48):7357-61. doi: 10.3748/wjg.v18.i48.7357. PubMed PMID: 23326145; PubMed Central PMCID: PMC3544042. 7: Tahara T, Shibata T, Okubo M, Yamashita H, Yoshioka D, Yonemura J, Maruyama N, Kamano T, Kamiya Y, Fujita H, Nakagawa Y, Nagasaka M, Iwata M, Yamada H, Nakamura M, Arisawa T, Hirata I. Examination of serum pepsinogen in functional dyspepsia. Hepatogastroenterology. 2012 Nov-Dec;59(120):2516-22. doi: 10.5754/hge10604. PubMed PMID: 23178618. 8: Zheng KC, Aoki K, Li XQ, Lin SG, Wu BS, Zhong WL, Chen TH, Lin S, You JW, Su C. Serum pepsinogens, gastrin-17 and Helicobacter pylori antibody in the residents of two cities in china with distinct mortality rates of gastric cancer. Tohoku J Exp Med. 2012;228(4):289-94. PubMed PMID: 23117263. 9: He CY, Sun LP, Gong YH, Xu Q, Dong NN, Yuan Y. Serum pepsinogen II: a neglected but useful biomarker to differentiate between diseased and normal stomachs. J Gastroenterol Hepatol. 2011 Jun;26(6):1039-46. doi: 10.1111/j.1440-1746.2011.06692.x. PubMed PMID: 21303408. 10: Sun LP, Gong YH, Dong NN, Wang L, Yuan Y. [Correlation of pepsinogen C (PGC) gene insertion/deletion polymorphism to PGC protein expression in gastric mucosa and serum]. Ai Zheng. 2009 May;28(5):487-92. Chinese. PubMed PMID: 19624876. 11: Iijima K, Abe Y, Kikuchi R, Koike T, Ohara S, Sipponen P, Shimosegawa T. Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal, healthy stomach. World J Gastroenterol. 2009 Feb 21;15(7):853-9. PubMed PMID: 19230047; PubMed Central PMCID: PMC2653386. 12: Sun LP, Zhang Y, Liu YE, Chen W, Yuan Y. [Interaction between an insertion/deletion polymorphism in pepsinogen C and Helicobacter pylori infection in the development of gastric cancer]. Zhonghua Zhong Liu Za Zhi. 2008 Sep;30(9):644-8. Chinese. PubMed PMID: 19173902. 13: Sun LP, Guo XL, Zhang Y, Chen W, Bai XL, Liu J, Yuan Y. Impact of pepsinogen C polymorphism on individual susceptibility to gastric cancer and its precancerous conditions in a Northeast Chinese population. J Cancer Res Clin Oncol. 2009 Aug;135(8):1033-9. doi: 10.1007/s00432-008-0539-3. Epub 2009 Jan 9. PubMed PMID: 19132389. 14: Pinto-Correia AL, Pinto D, Pereira D, Rodrigues H, de Sousa JA, Sousa H, Sousa B, Sousa S, Lopes C, Medeiros R. Overall survival in women with breast cancer: the influence of pepsinogen C gene polymorphism. DNA Cell Biol. 2008 Jun;27(6):333-6. doi: 10.1089/dna.2007.0713. PubMed PMID: 18447628. 15: Parthasarathy G, Maroju NK, Kate V, Ananthakrishnan N, Sridhar MG. Serum pepsinogen I and II levels in various gastric disorders with special reference to their use as a screening test for carcinoma stomach. Trop Gastroenterol. 2007 Oct-Dec;28(4):166-70. PubMed PMID: 18416347.

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