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Human Pepsin A-3(PGI) Recombinant Protein

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Data sheet of Human Pepsin A-3(PGI) Recombinant Protein

BrandProteoGenix
Product typeProteins
Origin speciesHuman
Host speciesMammalian

More info about Human Pepsin A-3(PGI) Recombinant Protein

Brand: ProteoGenix
Proteogenix reference: PX-P3000-10
Protein delivered with tag?: Yes
Size: 10 ug
Product name: Human Pepsin A-3(PGI) Recombinant Protein
Fragment type: Full-length
Origin species: Human
Expression system: Eukaryotic expression
Host species: Mammalian
Molecular weight with tag if any: 44.68 kDa
Purity estimated: 0.85
Spec:ncbi gene aliases: PGA3
Spec:swissprotid: P0DJD8.1
Ncbi reference: P0DJD8
Uniprot id: P0DJD8
Uniprot link: http://www.uniprot.org/uniprot/P0DJD8
Aliases / synonyms: EC 3.4.23; EC 3.4.23.1; FLJ58952; FLJ77962; pepsin A; pepsinogen 4, group I (pepsinogen A); Pepsinogen A; pepsinogen A4; PGA3; PGA5
Protein sequence (w/o tag): MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVAGSHHHHHH
Form: Frozen
Buffer: PBS, pH 7.5
Storage condition: 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Delivery condition: Dry Ice
Delivery lead time in business days: 5-7
Related products: - Human Gastricsin(PGII)/PGC Recombinant Protein
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Image: PX-P3000.jpg
Description: Human recombinant PAG3 (Pepsinogen 3, group I) belongs to the peptidase A1 family. Pepsinogens are the inactive precursors of pepsin, the main acid protease located in the stomach. Pepsin is one of the major proteolytic enzymes secreted by the gastric mucosa. Pepsin is specifically useful in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; Even though bonds involving phenylalanine and leucine are favored, a lot of others are also cleaved to some extent.
Publications: 1: Mansour-Ghanaei F, Joukar F, Rajpout Y, Hasandokht T. Screening of precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter pylori and anti- CagA antibodies in dyspeptic patients over 50 years old in Guilan Province, north of Iran. Asian Pac J Cancer Prev. 2014;15(18):7635-8. PubMed PMID: 25292040. 2: Shafaghi A, Mansour-Ghanaei F, Joukar F, Sharafkhah M, Mesbah A, Askari K, Geranmayeh S, Mehrvarz A, Souti F, Sokhanvar H, Fakhrieh S, Aminian K, Yousefi-Mashhour M, Khosh-Sorur M, Rasoulian J. Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions. Asian Pac J Cancer Prev. 2013;14(6):3931-6. PubMed PMID: 23886209. 3: Abe Y, Iijima K, Koike T, Asanuma K, Imatani A, Ohara S, Shimosegawa T. Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan. J Gastroenterol Hepatol. 2009 Jan;24(1):129-34. doi: 10.1111/j.1440-1746.2008.05691.x. PubMed PMID: 19196398. 4: Korsnes L, Gedde-Dahl T Jr. Genetics of pepsinogen I. Ann Hum Genet. 1980 Jan;43(3):199-212. PubMed PMID: 6767433. 5: Tu H, Sun L, Dong X, Gong Y, Xu Q, Jing J, Long Q, Flanders WD, Bostick RM, Yuan Y. Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study. Int J Cancer. 2015 Jan 15;136(2):425-34. doi: 10.1002/ijc.29005. Epub 2014 Jun 19. PubMed PMID: 24895149; PubMed Central PMCID: PMC4354768. 6: Peitz U, Wex T, Vieth M, Stolte M, Willich S, Labenz J, Jaspersen D, Lind T, Malfertheiner P. Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study. J Gastroenterol Hepatol. 2011 Jan;26(1):82-9. doi: 10.1111/j.1440-1746.2010.06413.x. PubMed PMID: 21175799. 7: Kamangar F, Diaw L, Wei WQ, Abnet CC, Wang GQ, Roth MJ, Liu B, Lu N, Giffen C, Qiao YL, Dawsey SM. Serum pepsinogens and risk of esophageal squamous dysplasia. Int J Cancer. 2009 Jan 15;124(2):456-60. doi: 10.1002/ijc.23918. PubMed PMID: 18844222; PubMed Central PMCID: PMC2605159. 8: Shiotani A, Iishi H, Uedo N, Kumamoto M, Nakae Y, Ishiguro S, Tatsuta M, Graham DY. Histologic and serum risk markers for noncardia early gastric cancer. Int J Cancer. 2005 Jun 20;115(3):463-9. PubMed PMID: 15688378. 9: Terasawa T, Nishida H, Kato K, Miyashiro I, Yoshikawa T, Takaku R, Hamashima C. Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis. PLoS One. 2014 Oct 14;9(10):e109783. doi: 10.1371/journal.pone.0109783. eCollection 2014. Review. PubMed PMID: 25314140; PubMed Central PMCID: PMC4196955. 10: Zhang XM, Li JX, Zhang GY, Li XH, Gu H. The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China. BMC Gastroenterol. 2014 Jan 3;14:3. doi: 10.1186/1471-230X-14-3. PubMed PMID: 24383519; PubMed Central PMCID: PMC3893538. 11: Huang M, Tang AG, Mu S, Yang JJ, Xiang ZY, Liu B, Yang JJ. Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay. J Clin Pathol. 2014 Apr;67(4):350-4. doi: 10.1136/jclinpath-2013-201942. Epub 2013 Oct 29. PubMed PMID: 24170207. 12: Kutsuma A, Oshida H, Suwa K, Nakajima K. A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men. Clin Biochem. 2014 Jan;47(1-2):126-8. doi: 10.1016/j.clinbiochem.2013.10.003. Epub 2013 Oct 11. PubMed PMID: 24125879. 13: Li P, He C, Sun L, Dong N, Yuan Y. Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease. BMC Clin Pathol. 2013 Sep 2;13(1):22. doi: 10.1186/1472-6890-13-22. PubMed PMID: 24004680; PubMed Central PMCID: PMC3846408. 14: Chae HD, Kim IH, Lee GH, Shin IH, Suh HS, Jeon CH. Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA. Am J Clin Pathol. 2013 Aug;140(2):209-14. doi: 10.1309/AJCPOHXRM5IYXVOC. PubMed PMID: 23897256. 15: Xu Q, Dong QG, Sun LP, He CY, Yuan Y. Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study. BMC Clin Pathol. 2013 Mar 22;13:11. doi: 10.1186/1472-6890-13-11. PubMed PMID: 23521833; PubMed Central PMCID: PMC3635921.

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